Metabolism fuels all biological processes. Metabolic dysfunction underlies the basis of many diseases including obesity, diabetes, cardiovascular disease, inflammation, and aging. Systemic homeostasis is achieved through coordinated metabolic regulation among different cells and multiple tissues & organs.
The ultimate long-term goal of my laboratory is to elucidate molecular mechanisms underlying the intercellular, inter-tissue, and inter-organ communication in maintaining the metabolic homeostasis. We utilize tools such as biochemistry, molecular and cellular biology, mouse genetics, and metabolomics to unravel the molecular underpinning of metabolic communication mediated by hormonal signals and nutritional cues.
Three major research directions in the lab: