Cellular metabolism fuels all biological processes. Metabolic dysfunction underlies the basis of many diseases including obesity, diabetes, cardiovascular disease, inflammation, and aging. Systemic homeostasis is achieved through coordinated metabolic regulation among different cells and multiple tissues & organs. The long-term goal of the Ruan laboratory is to elucidate molecular mechanisms underlying the intercellular communication in metabolic and immune systems.
We currently conduct an integrated program in three major directions.