Publications

Lin Z, Chen Q, Ruan HB. (2024). To die or not to die: Gasdermins in intestinal health and disease. Seminars in Immunology. 71:101865. doi: 10.1016/j.smim.2024.101865.

Zhang D, Tang W, Niu H, Tse W, Ruan HB, Dolznig H, Knösel T, Karl-Heinz F, Themanns M, Wang J, Song M, Denson L, Kenner L, Moriggl R, Zheng Y, Han X. (2024). Monogenic Deficiency in Murine Intestinal Cdc42 Leads to Mucosal Inflammation that Induces Crypt Dysplasia. Genes & Diseases. 11(1):413-429. doi: 10.1016/j.gendis.2022.11.024.

Huang Z, Gu C, Zhang Z, Arianti R, Swaminathan A, Tran K, Battist A, Kristof E, Ruan HB. (2023). Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors. PLOS Biology. 21(12): e3002413. doi: 10.1371/journal.pbio.3002413.

Zhang Z, Huang Z, Awad M, Elsalanty M, Cray J, Ball LE, Maynard JC, Burlingame AL, Zeng H, Mansky KC, Ruan HB. (2023). O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors. eLife. 12:e85464. doi: 10.7554/eLife.85464.

Xiong X, Huang R, Li Z, Yang C, Wang Q, Ruan HB, Xu L (2022). Intestinal Epithelial STAT6 Activation Rescues the Defective Anti-Helminth Responses Caused by Ogt Deletion. International Journal of Molecular Sciences. 23(19), 11137. doi:10.3390/ijms231911137.

Xiong X, Yang C, He WQ, Yu J, Xin Y, Zhang X, Huang R, Ma H, Xu S, Li Z, Ma J, Xu L, Wang Q, Ren K, Wu XS, Vakoc CR, Zhong J, Zhong G, Zhu X, Song Y, Ruan HB, Wang Q (2022). Sirtuin 6 maintains epithelial STAT6 activity to support intestinal tuft cell development and type 2 immunity. Nature Communications. 13: 5192. doi: 10.1038/s41467-022-32846-4.

Zhang Z, Salgado OC, Liu B, Moazzami Z, Hogquist KA, Farrar MA, Ruan HB (2022). An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism. Frontiers in Immunology. 13:874863. doi: 10.3389/fimmu.2022.874863.

Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB. (2022). Epithelial STAT6 O-GlcNAcylation drives anti-helminth immunity via a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Immunity. 55(4), 623–638. DOI: 10.1016/j.immuni.2022.03.009.

Huang Z, Zhang Z, Moazzami Z, Heck R, Hu P, Nanda H, Ren K, Sun Z, Bartolomucci A, Gao Y, Chung D, Zhu W, Shen S, Ruan HB (2022). Brown adipose tissue involution driven by progressive restriction in progenitor competence. Cell Reports. 39(2): 110575.DOI: 10.1016/j.celrep.2022.110575.

Zhou W, Jiang X, Tang Q, Ding L, Xiao W, Li J, Wu Y, Ruan HB, Shen Z, Chen W. (2022). Glucosamine facilitates cardiac ischemic recovery via recruiting Ly6C low monocytes in a STAT1 and O-GlcNAcylation-dependent fashion. Clin Transl Med. 12(3):e762. doi: 10.1002/ctm2.762.

Mohan R, Jo S, Chung EDS, Oribamise E, Lockridge A, Abrahante-Lloréns JE, Ruan HB, Yang X, Alejandro EU (2021). Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice. Cells. 10(10):2801. doi: 10.3390/cells10102801.

Zhao M, Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB. (2020). Protein O-GlcNAc modification links dietary and gut microbial cues to the differentiation of enteroendocrine L cells. Cell Reports. 32(6): 108013. doi: /10.1016/j.celrep.2020.108013

Ruan HB (2020) Developmental and functional heterogeneity of thermogenic adipose tissue. Journal of Molecular Cell Biology. doi: 10.1093/jmcb/mjaa029.

Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR 3rd, Han W, Sherwin RS, Nie Y, Yang X. (2020) O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth. Oncogene. 39:560–573. doi: 10.1038/s41388-019-0975-3.

Fang D, Shi X, Lu T, Ruan H, Gao Y. (2019) The glycoprotein follistatin-like 1 promotes brown adipose thermogenesis. Metabolism. 98:16-26. doi: 10.1016/j.metabol.2019.05.008

Liu R, Moriggl R, Zhang D, Li H, Karns R, Ruan HB, Niu H, Mayhew C, Watson C, Bangar H, Cha SW, Haslam D9, Zhang T, Gilbert S, Li N, Helmrath M, Wells J, Denson L, Han X. (2019) Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Sci Alliance. 2(2), e201900296. doi: 10.26508/lsa.201900296. 

Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB. (2019). Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. Haematologica. 104(9):1731-1743. doi: 10.3324/haematol.2018.205856.

Rauth M, Freund P, Orlova A, Grünert S, Tasic N, Han X, Ruan HB, Neubauer HA, Moriggl R. (2019). Cell metabolism control through O-GlcNAcylation of STAT5: a full or empty fuel tank makes a big difference for cancer cell growth and survival. International Journal of Molecular Sciences. 20(5), 1028. doi: 10.3390/ijms20051028. 

Xiong X, Yu J, Fan R, Zhang C, Xu L, Sun X, Huang Y, Wang Q, Ruan HB, Qian X. (2019). NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice. PLoS One. 14(2):e0212523. doi: 10.1371/journal.pone.0212523. 

Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB. (2019). The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation. Nature Communications. 10:354. doi: 10.1038/s41467-019-08300-3.

Wang Q, Tang J, Jiang S, Huang Z, Song A, Hou S, Gao X, Ruan HB. (2018). Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1. Journal of Endocrinology. 239(2):167-180. doi: 10.1530/JOE-18-0349.

Qian K, Wang S, Fu M, Zhou J, Singh JP, Li MD, Yang Y, Zhang K, Wu J, Nie Y, Ruan HB, Yang X. (2018). Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer. Journal of Biological Chemistry. 293(36):13989-14000. doi: 10.1074/jbc.RA118.004709.

Zhao M, Xiong XW, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB. (2018). Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation. EMBO Molecular Medicine. 10, e8736. doi: 10.15252/emmm.201708736.

Huang Y, Lia SC, Hu J, Ruan HB, Guo HM, Zhang HH, Wang X, Pei YF, Pan Y, Fang C. (2018). Gut Microbiota Profiling in Han Chinese with Type 1 Diabetes. Diabetes Research and Clinical Practice. 141:256-263. doi: 10.1016/j.diabres.2018.04.032.

Ruan HB, Crawford, PA. (2018). Ketone bodies as epigenetic modifiers. Current Opinion in Clinical Nutrition & Metabolic Care. 21(4):260-266. doi: 10.1097/MCO.0000000000000475.

Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. (2017). Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes & Development. 31(16): 1655-1665.

Wang W, Meng X, Yang C, Fang D, Wang X, An J, Zhang J, Wang L, Lu T, Ruan HB, Gao Y. (2017). Brown adipose tissue activation in a rat model of Parkinson's disease. American Journal of Physiology-Endocrinology and Metabolism. 313(6): E731-E736.

Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. (2017). Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liver. Hepatology Communicatons. 1(1): 23-35.

Zhou T, Erber L, Liu B, Gao Y, Ruan HB, Chen Y. (2016). Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cells. Oncotarget. 7(48): 79154-79169.

Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N. (2016). MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels. Nature Communications. 7:12639.

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. (2016). Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation. Molecular Cell. 62(2):194-206.

Yang, X, Ruan HB. (2015). Neuronal control of adaptive thermogenesis. Frontiers in Endocrinology. 6:149.

Bindesboll C, Fan Q, Norgaard RC, MacPherson L, Ruan HB, Wu J, Pedersen TA, Steffensen KR, Yang X, Matthews J, Mandrup S, Nebb HI, Gronning-Wang L. (2015). Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. Journal of Lipid Research. 56(4): 771-785.

Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. (2015). Hepatic acetyl CoA regulates insulin action and links adipose tissue inflammation with hepatic insulin resistance and type 2 diabetes. Cell. 160(4): 745-758.

Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. (2014). O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell. 159(2): 306-317.

Huang Z*, Ruan HB*, Xian L, Chen W, Jiang S, Song A, Wang Q, Shi P, Gu X, Gao X. (2014) The stem cell factor/Kit signaling pathway regulates mitochondrial function and energy expenditure. Nature Communications. 5:4282.

Lee Y, Dominy JE, Choi YJ, Jurczak MJ, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. (2014). Cyclin D1-CDK4 controls glucose metabolism independently of cell cycle progression. Nature. 510(7506): 547-551.

Huang Z*, Ruan HB*, Zhang ZD, Chen W, Lin Z, Zeng H, Gao X. (2014). Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in mice. The American Journal of Pathology. 184(1): 122-132.

Ruan HB, Nie Y, Yang, X. (2013). Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination. Molecular & Cellular Proteomics. 12(12): 3489-97.

Ruan HB, Singh JP, Li MD, Wu J, Yang, X. (2013). Cracking the O-GlcNAc code in metabolism. Trends in Endocrinology & Metabolism. 24(6): 301-309.

Li MD, Ruan HB, Hughes ME, Lee JS, Singh JP, Jones SP, Nitabach MN, Yang, X. (2013). O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination. Cell Metabolism. 17(2): 303-310.

Dominy JE, Lee Y, Jedrychowski M, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. (2012). The deacetylase SirT6 activates the acetyl transferase GCN5 and suppresses hepatic gluconegeonesis. Molecular Cell. 48(6): 900-913.

Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR, Yang X. (2012). O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability. Cell Metabolism. 16(2): 226-237.

Li MD, Ruan HB, Singh JP, Zhao L, Zhao T, Azarhoush S, Wu J, Evans RM, Yang X. (2012). O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression. The Journal of Biological Chemistry. 287(16): 12904-12.

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. (2011). Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine. 17(9): 1121-1127.

Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X. Protein phosphatase 2A catalytic subunit alpha maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. The American Journal of Pathology. 2011; 178 (5): 2333-2343.

Chen W, Li C, Jiang X, Ruan H, Qi X, Liu L, Zhao Q, Gao X. (2010). Overexpressing dominant negative MyD88 induces cardiac dysfunction in transgenic mice. Chinese Science Bulletin. 55(31): 3569−3575.

Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y. (2010). Interaction of MAGED1 with nuclear receptors affects circadian clock function. The EMBO Journal. 29(8): 1389-1400.

Guo XL, Ruan HB, Li Y, Gao X, Li W. (2010). Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-Kit. Pigment Cell & Melanoma Research. 23(2): 252-262.

Ruan HB, Zhang N, and Gao X. (2005). Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis. Genetics. 169(2): 819-831.

He F, Wang Z, Zhao J, Bao J, Ding J, Ruan H, Xie Q, Zhang Z, Gao X. (2003). Large-scale screening of disease model through ENU mutagenesis in mice. Chinese Science Bulletin. 48(24): 2665-2671.