Publications

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2020

Zhao M, Ren K, Xiong X, Cheng M, Zhang Z, Huang Z, Han X, Yang X, Alejandro EU, Ruan HB. (2020). Protein O-GlcNAc modification links dietary and gut microbial cues to the differentiation of enteroendocrine L cellsCell Reports. 32(6): 108013. doi: /10.1016/j.celrep.2020.108013

Ruan HB (2020) Developmental and functional heterogeneity of thermogenic adipose tissueJournal of Molecular Cell Biology. doi: 10.1093/jmcb/mjaa029.

Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR 3rd, Han W, Sherwin RS, Nie Y, Yang X. (2020) O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growthOncogene. 39:560–573. doi: 10.1038/s41388-019-0975-3.

2019

Fang D, Shi X, Lu T, Ruan H, Gao Y. (2019) The glycoprotein follistatin-like 1 promotes brown adipose thermogenesisMetabolism. 98:16-26. doi: 10.1016/j.metabol.2019.05.008

Liu R, Moriggl R, Zhang D, Li H, Karns R, Ruan HB, Niu H, Mayhew C, Watson C, Bangar H, Cha SW, Haslam D9, Zhang T, Gilbert S, Li N, Helmrath M, Wells J, Denson L, Han X. (2019) Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis. Life Sci Alliance. 2(2), e201900296. doi: 10.26508/lsa.201900296. 

Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB. (2019). Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. Haematologica. 104(9):1731-1743. doi: 10.3324/haematol.2018.205856.

Rauth M, Freund P, Orlova A, Grünert S, Tasic N, Han X, Ruan HB, Neubauer HA, Moriggl R. (2019). Cell metabolism control through O-GlcNAcylation of STAT5: a full or empty fuel tank makes a big difference for cancer cell growth and survivalInternational Journal of Molecular Sciences. 20(5), 1028. doi: 10.3390/ijms20051028. 

Xiong X, Yu J, Fan R, Zhang C, Xu L, Sun X, Huang Y, Wang Q, Ruan HB, Qian X. (2019). NAMPT overexpression alleviates alcohol-induced hepatic steatosis in micePLoS One. 14(2):e0212523. doi: 10.1371/journal.pone.0212523. 

Liu B, Salgado OC, Singh S, Hippen KL, Maynard JC, Burlingame AL, Ball LE, Blazar BR, Farrar MA, Hogquist KA, Ruan HB. (2019). The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylationNature Communications. 10:354. doi: 10.1038/s41467-019-08300-3.

2018

Wang Q, Tang J, Jiang S, Huang Z, Song A, Hou S, Gao X, Ruan HB. (2018). Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1Journal of Endocrinology. 239(2):167-180. doi: 10.1530/JOE-18-0349.

Qian K, Wang S, Fu M, Zhou J, Singh JP, Li MD, Yang Y, Zhang K, Wu J, Nie Y, Ruan HB, Yang X. (2018). Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancerJournal of Biological Chemistry. 293(36):13989-14000. doi: 10.1074/jbc.RA118.004709.

Zhao M, Xiong XW, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB. (2018). Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammationEMBO Molecular Medicine. 10, e8736. doi: 10.15252/emmm.201708736.

Huang Y, Lia SC, Hu J, Ruan HB, Guo HM, Zhang HH, Wang X, Pei YF, Pan Y, Fang C. (2018). Gut Microbiota Profiling in Han Chinese with Type 1 DiabetesDiabetes Research and Clinical Practice. 141:256-263. doi: 10.1016/j.diabres.2018.04.032.

Ruan HB, Crawford, PA. (2018). Ketone bodies as epigenetic modifiersCurrent Opinion in Clinical Nutrition & Metabolic Care. 21(4):260-266. doi: 10.1097/MCO.0000000000000475.

2017

Ruan HB, Ma Y, Torres S, Zhang B, Feriod C, Heck RM, Qian K, Fu M, Li X, Nathanson MH, Bennett AM, Nie Y, Ehrlich BE, Yang X. (2017). Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvationGenes & Development. 31(16): 1655-1665.

Wang W, Meng X, Yang C, Fang D, Wang X, An J, Zhang J, Wang L, Lu T, Ruan HB, Gao Y. (2017). Brown adipose tissue activation in a rat model of Parkinson's diseaseAmerican Journal of Physiology-Endocrinology and Metabolism. 313(6): E731-E736.

Feriod CN, Oliveira AG, Guerra MT, Nguyen L, Richards KM, Jurczak MJ, Ruan HB, Camporez JP, Yang X, Shulman GI, Bennett AM, Nathanson MH, Ehrlich BE. (2017). Hepatic inositol 1,4,5 trisphosphate receptor type 1 mediates fatty liverHepatology Communicatons. 1(1): 23-35.

2016

Zhou T, Erber L, Liu B, Gao Y, Ruan HB, Chen Y. (2016). Proteomic analysis reveals diverse proline hydroxylation-mediated oxygen-sensing cellular pathways in cancer cellsOncotarget. 7(48): 79154-79169.

Nagarajan A, Petersen MC, Nasiri AR, Butrico G, Fung A, Ruan HB, Kursawe R, Caprio S, Thibodeau J, Bourgeois-Daigneault MC, Sun L, Gao G, Bhanot S, Jurczak MJ, Green MR, Shulman GI, Wajapeyee N. (2016). MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levelsNature Communications. 7:12639.

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y. (2016). Metabolic Regulation of Gene Expression by Histone Lysine β-HydroxybutyrylationMolecular Cell. 62(2):194-206.

2015

Yang, X, Ruan HB. (2015). Neuronal control of adaptive thermogenesisFrontiers in Endocrinology. 6:149.

Bindesboll C, Fan Q, Norgaard RC, MacPherson L, Ruan HB, Wu J, Pedersen TA, Steffensen KR, Yang X, Matthews J, Mandrup S, Nebb HI, Gronning-Wang L. (2015). Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activityJournal of Lipid Research. 56(4): 771-785.

Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI. (2015). Hepatic acetyl CoA regulates insulin action and links adipose tissue inflammation with hepatic insulin resistance and type 2 diabetesCell. 160(4): 745-758.

2014

Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. (2014). O-GlcNAc transferase enables AgRP neurons to suppress browning of white fatCell. 159(2): 306-317.

Huang Z*, Ruan HB*, Xian L, Chen W, Jiang S, Song A, Wang Q, Shi P, Gu X, Gao X. (2014) The stem cell factor/Kit signaling pathway regulates mitochondrial function and energy expenditureNature Communications. 5:4282.

Lee Y, Dominy JE, Choi YJ, Jurczak MJ, Tolliday N, Camporez JP, Chim H, Lim JH, Ruan HB, Yang X, Vazquez F, Sicinski P, Shulman GI, Puigserver P. (2014). Cyclin D1-CDK4 controls glucose metabolism independently of cell cycle progressionNature. 510(7506): 547-551.

Huang Z*, Ruan HB*, Zhang ZD, Chen W, Lin Z, Zeng H, Gao X. (2014). Mutation in the first Ig-like domain of Kit leads to JAK2 activation and myeloproliferation in miceThe American Journal of Pathology. 184(1): 122-132.

2013

Ruan HB, Nie Y, Yang, X. (2013). Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitinationMolecular & Cellular Proteomics. 12(12): 3489-97.

Ruan HB, Singh JP, Li MD, Wu J, Yang, X. (2013). Cracking the O-GlcNAc code in metabolismTrends in Endocrinology & Metabolism. 24(6): 301-309.

Li MD, Ruan HB, Hughes ME, Lee JS, Singh JP, Jones SP, Nitabach MN, Yang, X. (2013). O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitinationCell Metabolism. 17(2): 303-310.

2012

Dominy JE, Lee Y, Jedrychowski M, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. (2012). The deacetylase SirT6 activates the acetyl transferase GCN5 and suppresses hepatic gluconegeonesisMolecular Cell. 48(6): 900-913.

Ruan HB, Han X, Li MD, Singh JP, Qian K, Azarhoush S, Zhao L, Bennett AM, Samuel VT, Wu J, Yates JR, Yang X. (2012). O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stabilityCell Metabolism. 16(2): 226-237.

Li MD, Ruan HB, Singh JP, Zhao L, Zhao T, Azarhoush S, Wu J, Evans RM, Yang X. (2012). O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepressionThe Journal of Biological Chemistry. 287(16): 12904-12.

2005-2011

Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, Mobbs CV, Yang X, Gao XB, Horvath TL. (2011). Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesityNature Medicine. 17(9): 1121-1127.

Chen W, Gu P, Jiang X, Ruan HB, Li C, Gao X. Protein phosphatase 2A catalytic subunit alpha maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathwayThe American Journal of Pathology. 2011; 178 (5): 2333-2343.

Chen W, Li C, Jiang X, Ruan H, Qi X, Liu L, Zhao Q, Gao X. (2010). Overexpressing dominant negative MyD88 induces cardiac dysfunction in transgenic miceChinese Science Bulletin. 55(31): 3569−3575.

Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y. (2010). Interaction of MAGED1 with nuclear receptors affects circadian clock functionThe EMBO Journal. 29(8): 1389-1400.

Guo XL, Ruan HB, Li Y, Gao X, Li W. (2010). Identification of a novel nonsense mutation on the Pax3 gene in ENU-derived white belly spotting mice and its genetic interaction with c-KitPigment Cell & Melanoma Research. 23(2): 252-262.

Ruan HB, Zhang N, and Gao X. (2005). Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesisGenetics. 169(2): 819-831.

He F, Wang Z, Zhao J, Bao J, Ding J, Ruan H, Xie Q, Zhang Z, Gao X. (2003). Large-scale screening of disease model through ENU mutagenesis in miceChinese Science Bulletin. 48(24): 2665-2671.

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Research highlights:


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